All the key players are now in place to make the post-antibiotic world a reality. If MRC-1 [a gene mutation resistant to drugs] becomes global, which is a case of when not if, and the gene aligns itself with other antibiotic resistance genes, which is inevitable, then we will have very likely reached the start of the post-antibiotic era. At that point if a patient is seriously ill, say with E. coli, then there is virtually nothing you can do.